Occult Bone Metastases From Hepatocellular Carcinoma Detected on 68Ga-PMSA PET/CT. (August 2021)

• Record Type: Journal Article
• Authors: Usmani, Sharjeel; Rasheed, Rashid; Al Kandari, Fareeda; Ahmed, Najeeb
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 8(2021)
• Publication Date: 2021-08
• Subjects: 68Ga-PSMA PET/CT -- hepatocellular carcinoma -- angiogenesis -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003515
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: 68 Ga-PSMA is an excellent radiotracer for both staging and detection of recurrence in prostate cancer, but it can also be useful in other solid tumors due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of an 82-year-old man with hepatocellular carcinoma who presented with rising tumor marker but stable CT findings 6 months after transarterial chemoembolization. 68 Ga-PSMA PET/CT showed high PSMA-expressing hyperneovascular hepatic lesions (primary tumor), additional multifocal hepatic lesions, and with unexpected multiple bone metastases. 68 Ga-PSMA expression in hepatocellular carcinoma can influence patient management and potentially guide radionuclide legend therapy.