C-reactive protein-to-serum albumin ratio as a novel predictor of long-term outcomes in coronary artery disease patients who have undergone percutaneous coronary intervention: analysis of a real-world retrospective cohort study. Issue 3 (May 2021)

• Record Type: Journal Article
• Authors: Liu, Zhi-Yu; Tang, Jun-Nan; Cheng, Meng-Die; Jiang, Li-Zhu; Guo, Qian-Qian; Zhang, Jian-Chao; Zhang, Zeng-Lei; Song, Feng-Hua; Wang, Kai; Fan, Lei; Yue, Xiao-Ting; Bai, Yan; Dai, Xin-Ya; Zheng, Ru-Jie; Zheng, Ying-Ying; Zhang, Jin-Ying
• Is Part Of: Coronary artery disease. Volume 32:Issue 3(2021)
• Publication Date: 2021-05
• Subjects: all-cause mortality -- C-reactive protein-to-serum albumin ratio -- cardiac mortality -- coronary artery disease -- percutaneous coronary intervention; Coronary heart disease -- Periodicals; Coronary Disease -- Indexes; Coronary Disease -- Periodicals; 616.123005
• DOI: 10.1097/MCA.0000000000001021
• Languages: English
• ISSNs: 0954-6928

Abstract

Abstract : Background: C-reactive protein (CRP) has been proposed as a contributor to the pathogenesis of coronary artery disease (CAD) and inflammatory reactions, which are associated with a decrease in serum albumin, and it has been reported that the CRP-to-serum albumin ratio (CAR) can predict CAD severity in inpatient ischemic cardiomyopathy (ICM) patients. However, the relationship between the CAR and long-term adverse outcomes in CAD patients after percutaneous coronary intervention (PCI) is still unknown. Methods: A total of 3561 CAD patients enrolled in the Outcomes and Risk Factors of Patients with Coronary Heart Disease after PCI: an investigation based on case records and follow-up (CORFCHD-ZZ), a retrospective cohort study conducted from January 2013 to December 2017, and 1630 patients meeting the study inclusion criteria were divided into two groups based on the CAR (CAR < 0.186; n = 1301 and CAR ≥ 0.186; n = 329). The primary outcome was long-term mortality, including all-cause mortality (ACM) and cardiac mortality. The average follow-up time was 37.59 months. Results: We found that there were significant differences between the two groups in the incidences of ACM ( P < 0.001) and cardiac mortality ( P = 0.003). Cox multivariate regression analyses demonstrated that CAR was an independent predictor of ACM [hazard ratio, 2.678; (95% confidence interval (CI), 1.568–4.576); P < 0.001] and cardiac mortality (hazard ratio, 2.055; 95% CI, 1.056–3.998; P = 0.034) in CAD patients after PCI. Conclusion: This study revealed that the CAR is an independent and novel predictor of long-term adverse outcomes in CAD patients who have undergone PCI.