Alpha and gamma EEG coherence during on-task and mind wandering states in schizophrenia. (February 2023)

• Record Type: Journal Article
• Authors: Prieto-Alcántara, Marta; Ibáñez-Molina, Antonio; Crespo-Cobo, Yasmina; Molina, Rosa; Soriano, María Felipa; Iglesias-Parro, Sergio
• Is Part Of: Clinical neurophysiology. Volume 146(2023)
• Page Start: 21
• Page End: 29
• Publication Date: 2023-02
• Subjects: EEG Coherence -- Schizophrenia -- Healthy control -- Mind-wandering -- Cognitive processing; EEG electroencephalography -- SCZ schizophrenia -- MW mind wandering, -- DMN default Mode Network; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.11.010
• Languages: English
• ISSNs: 1388-2457

Abstract

Graphical abstract: Highlights: The differences in alpha-band EEG coherence between patients with schizophrenia and healthy controls are expressed in different cortical regions. Differences in alpha band coherence between patients and controls are reduced in mind wandering states. Coherence in the Gamma band does not allow discrimination between patients and controls, either in mind wandering states or when they are focused on a task. Abstract: Objective: Electroencephalographic (EEG) coherence is one of the most relevant physiological measures used to detect abnormalities in patients with schizophrenia. The present study applies a task-related EEG coherence approach to understand cognitive processing in patients with schizophrenia and healthy controls. Methods: EEG coherence for alpha and gamma frequency bands was analyzed in a group of patients with schizophrenia and a group of healthy controls during the performance of an ecological task of sustained attention. We compared EEG coherence when participants presented externally directed cognitive states (On-Task) and when they presented cognitive distraction episodes (Mind-Wandering). Results: Results reflect cortical differences between groups (higher coherence for schizophrenia in the frontocentral and fronto-temporal regions, and higher coherence for healthy-controls in the postero-central regions), especially in the On-Task condition for the alpha band, compared to Mind-Wandering episodes. Few individual differences in gamma coherence were found. Conclusions: The current study provides evidence of neurophysiological differences underlying different cognitive states in schizophrenia and healthy controls. Significance: Differences between groups may reflect inhibitory processes necessary for the successful processing of information, especially in the alpha band, given its role in cortical inhibition processes. Patients may activate compensatory inhibitory mechanisms when performing the task, reflected in increased coherence in fronto-temporal regions.