68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors. (June 2021)

• Record Type: Journal Article
• Authors: Lococo, Filippo; Rufini, Vittoria; Filice, Angelina; Paci, Massimiliano; Rindi, Guido
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 6(2021)
• Publication Date: 2021-06
• Subjects: 68Ga-DOTATOC -- positron emission tomography -- solitary fibrous tumor -- pleural tumor -- somatostatin receptors; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003570
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68 Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68 Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.