A case of NUT midline carcinoma with no HPV infection, slight EWSR1rearrangement and strong expression of EGFR. Issue 4 (July 2013)

• Record Type: Journal Article
• Authors: Maffini, Fausto; French, Christopher Alexander; Cameron, Michael James; Stufano, Viviana; Barberis, Massimo; Pisa, Eleonora; Manzotti, Michela; Cattaneo, Augusto; De Fiori, Elvio; Viale, Giuseppe
• Is Part Of: Tumori. Volume 99:Issue 4(2013)
• Page Start: e152
• Page End: e155
• Publication Date: 2013-07
• Subjects: Ewing sarcoma -- larynx carcinoma -- HPV -- PCR -- immunohistochemistry -- squamous cell carcinoma -- NUT midline carcinoma; Cancer -- Periodicals; 616.994
• DOI: 10.1177/030089161309900423
• Languages: English
• ISSNs: 0300-8916

Abstract

NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV infection, EWSR1 rearrangement, and the status of the EGFR gene.