68Ga-FAPI PET/CT in Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy. (May 2021)

• Record Type: Journal Article
• Authors: Fu, Hao; Fu, Jie; Huang, Jingxiong; Su, Xinyi; Chen, Haojun
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 5(2021)
• Publication Date: 2021-05
• Subjects: 68Ga-FAPI -- DTC -- TENIS -- thyroid cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003569
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Differentiated thyroid cancer with thyroglobulin elevation and negative iodine scintigraphy (TENIS) syndrome is a diagnostic and therapy dilemma. In this study, we present a case of TENIS with detectable metastases in the larynx and lung on the CT scan. 68 Ga-fibroblast activation protein inhibitor (FAPI) PET/CT was performed for further detection of tumor recurrence and metastases, which showed intense 68 Ga-FAPI activity in the metastatic lesions. To the best of our knowledge, this is the first case of TENIS presenting with FAPI-avid metastatic lesions, demonstrating its usefulness for localizing recurrent or metastatic lesions in patients with TENIS.