Left Ventricular Mass is Independently Related to Coronary Artery Atherosclerotic Burden: Feasibility of Cardiac Computed Tomography to Detect Early Geometric Left Ventricular Changes. Issue 3 (May 2021)

• Record Type: Journal Article
• Authors: Walpot, Jeroen; Massalha, Samia; Hossain, Alomgir; Small, Gary R.; Crean, Andrew M.; Yam, Yeung; Rybicki, Frank J.; Inácio, João R.; Chow, Benjamin J.W.
• Is Part Of: Journal of thoracic imaging. Volume 36:Issue 3(2021)
• Publication Date: 2021-05
• Subjects: computed tomography coronary angiography -- coronary artery disease -- left ventricular mass indexed to body surface area -- Total Plaque Score -- Agatston Score -- concentricity index; Chest -- Radiography -- Periodicals; Chest -- Diseases -- Diagnosis -- Periodicals; 617.540757
• DOI: 10.1097/RTI.0000000000000511
• Languages: English
• ISSNs: 0883-5993

Abstract

Abstract : Background: Left ventricular mass (LVM) is a predictor for adverse cardiovascular outcomes. Coronary atherosclerosis (coronary artery disease [CAD]) and concentric left ventricular (LV) remodeling are linked pathophysiologically by endothelial dysfunction. Aim: This study sought to determine the potential association between coronary atherosclerosis and LVM. Methods: A total of 2384 consecutive patients, without structural heart disease or a medical history of CAD, undergoing prospective mid-diastolic electrocardiogram-gated computed tomography coronary angiography were enrolled in the study. LVM and LV mid-diastolic volume were measured using semiautomated software and indexed to body surface area. The average LV mid-diastolic wall thickness and concentricity index (LVM/LV mid-diastolic volume) were calculated. According to the Agatston Score, the patients were divided into 3 groups (Agatston=0, 0.1 to 399.9, ≥400). Similarly, patients were also divided into 4 groups on the basis of the Total Plaque Score (TPS) (0, 1 to 4, 5 to 8, and ≥9). In addition, patients were categorized according to CAD (normal coronaries, nonobstructive CAD, and obstructive stenosis [obstruction >50%]). The association between the different categories of CAD and LV measures was assessed. Results: Both left ventricular mass index (LVMi) and the LV concentricity index increased with TPS categories from 55.3±12.1, 57.4±11.7, 60.9±13.6, and 63.7±15.3 g/m 2 ( P <0.05), and 0.935±0.424, 0.975±0.3273, 1.046±0.431, and 1.138±0.443 mL/g ( P <0.01), respectively. A similar trend of increasing LVMi was observed with increasing Agatston Score ( P <0.001) and CAD category ( P <0.05). Conclusion: In patients without known structural heart disease, LVMi is independently associated with measures of CAD. Abstract : Supplemental Digital Content is available in the text.