Using longitudinal genetic-network study to understand HIV treatment-as-prevention. (1st May 2021) - Kang, Ruihua
Abstract : Objective: The WHO has recommended that antiretroviral therapy be provided to all HIV patients to reduce future HIV transmission rates. However, few studies have examined this public health strategy at the population level in a real-world setting. Methods: In this longitudinal genetic-network study in Guangxi, China, the baseline and follow-up data were collected from HIV patients in 2014 and newly diagnosed HIV patients from 2015 to 2018, respectively. The prevention efficacy was used to estimate the effect of treatment-as-prevention in reducing HIV secondary transmission. Results: Among 804 newly diagnosed HIV patients during 2015–2018, 399 (49.6%) of them genetically linked to HIV patients at baseline during 2014–2017. The overall proportion of genetic linkage between newly diagnosed HIV patients during 2015–2018 with untreated and treated HIV patients at baseline during 2014–2017 was 6.2 and 2.9%, respectively. The prevention efficacy in HIV transmission for treated HIV patients was 53.6% [95% confidence interval (95% CI): 42.1–65.1]. Subgroup analyses indicated an 80.3% (95% CI: 74.8–85.8) reduction in HIV transmission among HIV patients who were treated for 4 years or more and had viral loads less than 50 copies/ml. There was no significant reduction in HIV transmission among treated HIV patients who dropped out or who had missing viral load measures. Conclusion: Our study results support the feasibility of treating all HIV patients for future reductions in HIV transmission at the population level in real-world settings. Comprehensive intervention prevention programmes are urgently needed. Abstract : Supplemental Digital Content is available in the text