Aptamer Immobilized Field Effect Transistor for Early Diagnostic of Human Immunodeficiency Virus Type 1 (HIV-1). (11th September 2015)

• Record Type: Journal Article
• Authors: Chu, Chia-Ho; Sarangadharan, Indu; Regmi, Abiral; Chen, Yi-Ting; Wang, Yu-Lin
• Is Part Of: ECS transactions. Volume 69:Number 13(2015)
• Page Start: 25
• Page End: 29
• Publication Date: 2015-09-11
• Subjects: Electrochemistry -- Periodicals; Electrochemistry; Periodicals; Electronic journals; Electronic journal; 541.37
• DOI: 10.1149/06913.0025ecst
• Languages: English
• ISSNs: 1938-5862

Abstract

Abstract : In recent years, aptamer-based biosensors have aroused great interest in detecting different targets, such as proteins, peptides and whole cells. In contrast to antibodies-based biosensors, the selected aptamer can be synthesized with high reproducibility. Also, aptamers are usually chemically stable. In this study, we demonstrated HIV-1 RT-specific aptamers-immobilized AlGaN/GaN high electron mobility transistors (HEMTs) for detecting different concentrations of HIV-1 RT protein ranging from 1 fM to 10 pM in physiological salt concentrations.