Development and analysis of a mathematical model for a synthetic biological cell. Issue 1 (2015)

• Record Type: Journal Article
• Authors: Schneider, Eugenia; Mangold, Michael
• Is Part Of: IFAC-PapersOnLine. Volume 48:Issue 1(2015)
• Page Start: 447
• Page End: 452
• Publication Date: 2015
• Subjects: nonlinear systems -- simulation -- synthetic biology -- protocell -- biocybernetics; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2015.05.018
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: Synthetic biology as a new discipline is driven by progresses made in the understanding of microbiological processes and its mathematical description by system biological models. The topic of synthetic biology is a systematic construction of artificial biological systems with tailored properties. The subject of this work is to develop an artificial cell model consisting of functional biological devices like genome, transcriptome, proteome, metabolome, with a structure that guarantees a synchronization of the devices in a robust way. The mathematical model shown in this work involves the metabolism, the polymerization subsystem and the membrane. The model structure enables an oscillatory behavior of the system with a stable limit cycle. Also the system provides a robust self-replicating state and a biological robustness with respect to parameter uncertainties.