Exploring Helical Peptides and Foldamers for the Design of Metal Helix Frameworks: Current Trends and Future Perspectives. Issue 6 (15th December 2022)

• Record Type: Journal Article
• Authors: Bajpayee, Nikhil; Vijayakanth, Thangavel; Rencus‐Lazar, Sigal; Dasgupta, Sneha; Desai, Aamod V.; Jain, Rahul; Gazit, Ehud; Misra, Rajkumar
• Is Part Of: Angewandte Chemie international edition. Volume 62:Issue 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-15
• Subjects: Biocompatibility -- Foldamers -- Helical Peptides -- Metal-Helix Frameworks -- Porous Structures; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202214583
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Flexible and biocompatible metal peptide frameworks (MPFs) derived from short and ultra‐short peptides have been explored for the storage of greenhouse gases, molecular recognition, and chiral transformations. In addition to short flexible peptides, peptides with specifically folded conformations have recently been utilized to fabricate a variety of metal helix frameworks (MHFs ). The secondary structures of the peptides govern the structure‐assembly relationship and thereby control the formation of three‐dimensional (3D)‐MHFs . Particularly, the hierarchical structural organization of peptide‐based MHFs has not yet been discussed in detail. Here, we describe the recent progress of metal‐driven folded peptide assembly to construct 3D porous structures for use in future energy storage, chiral recognition, and biomedical applications, which could be envisioned as an alternative to the conventional metal‐organic frameworks (MOFs). Abstract : This review summarizes the recent progress of metal peptide frameworks (MPFs) comprised of helical peptides and foldamers for future energy storage, chiral recognition, and biomedical applications.