Controlled Construction of Heteroleptic [Pd2(LA)2(LB)(LC)]4+ Cages: A Facile Approach for Site‐Selective endo‐Functionalization of Supramolecular Cavities. (9th January 2023)

• Record Type: Journal Article
• Authors: Liu, Yan; Liao, Shou‐Heng; Dai, Wen‐Tao; Bai, Qixia; Lu, Shuai; Wang, Heng; Li, Xiaopeng; Zhang, Zhe; Wang, Pingshan; Lu, Wei; Zhang, Qi
• Is Part Of: Angewandte Chemie. Volume 135:Number 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-09
• Subjects: Endo-Functionalization -- Heteroleptic Assemblies -- Metal-Ligand Supramolecular Structures -- Supramolecular Chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202217215
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Construction of supramolecular structures with internal functionalities is a promising approach to build enzyme‐like cavities. The endo‐functionalized [Pd12 L24 ] and [Pd2 L4 ] coordination cages represent the most successful systems in this regard. However, these systems mainly contain one type of endo‐moiety. We herein provide a solution for the controlled endo‐functionalization of [Pd2 L4 ] cages. Site‐selective introduction of the endo‐functional group was achieved through the formation of heteroleptic [Pd2 (L A )2 (L B )(L C )] cages. Using two orthogonal steric control elements is the key for the selective formation of the hetero‐assemblies. We demonstrated the construction of two hetero‐cages with a single internal functional group as well as a hetero‐cage with two distinct endohedral functionalities. The endo‐functionalized hetero‐cages bound sulfonate guests with fast‐exchange dynamics. This strategy provides a new solution for the controlled endo‐functionalization of supramolecular cavities. Abstract : Unprecedented heteroleptic [Pd2 L A )2 L B ) L C )] supramolecular cages were selectively constructed by taking advantage of a pair of orthogonal steric control elements encoded in distinct ligands. This strategy allows the site‐selective introduction of distinct endo‐functionalities into the cavity of the heteroleptic cage.