Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease. (8th December 2022)

• Record Type: Journal Article
• Authors: Sinclair, Lindsey Isla; Ballard, Clive G.
• Is Part Of: International journal of geriatric psychiatry. Volume 38:Number 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-08
• Subjects: Alzheimer's disease -- dementia -- depression -- depressive disorder; Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.5858
• Languages: English
• ISSNs: 0885-6230

Abstract

Abstract: Background: Depression in individuals with Alzheimer's disease (AD) is common, difficult to treat and inadequately understood. Previous studies have identified possible differences in regional brain atrophy in individuals with AD and depression, but the results have been inconsistent and some studies had less robust definitions of depression. We aimed to examine regional brain atrophy in two large dementia focused cohorts. Methods: We used data from Alzheimer's disease neuroimaging initiative (ADNI) and the National Alzheimer's Co‐ordinating Center (NACC), for those with data from at least one MRI scan. Depression ratings were available using the Geriatric Depression Scale (GDS) and Neuropsychiatric Inventory (NPI). Intermittent depressive symptoms were defined as one episode above threshold (≥8 on GDS, ≥6 on NPI depression subscale and ≥2 on the Neuropsychiatric Inventory version Q depression sub‐scale) and persistent as ≥2 episodes. Derived regional volumetric data was available from ADNI and the NACC. Results: Data was available from 698 individuals with AD in NACC and from 666 individuals in ADNI. We found no evidence of between group differences in regional brain volume at baseline, or of differential atrophy in NACC. In ADNI we found evidence of increased brain atrophy in several frontal brain areas. Limitations: Because this study was limited to those with MRI data, the numbers in some analyses were low. MRI parcellation differed between studies making direct comparison difficult. For some individuals only the NPI was used to rate depression. Conclusions: We have found mixed evidence of increased regional atrophy in depression in AD, mainly in frontal brain regions. We found no evidence to support a vascular basis for depression in AD. Key points: We found, unlike some previous studies, that there was no evidence of differences in regional brain volumes at baseline. Likewise we found no evidence to support a link between depression in AD and increased white matter hyperintensities. We found in Alzheimer's disease neuroimaging initiative, but not in National Alzheimer's Co‐ordinating Center, that persistent depression in those with AD may be associated with greater regional atrophy in several brain areas which were predominantly frontal