Multi-responsive on-demand drug delivery PMMA-co-PDEAEMA platform based on CO2, electric potential, and pH switchable nanofibrous membranes. Issue 3 (11th February 2023)

• Record Type: Journal Article
• Authors: Gorji, Mohsen; Zarbaf, Dara; Mazinani, Saeedeh; Noushabadi, Abolfazl Sajadi; Cella, Monica A.; Sadeghianmaryan, Ali; Ahmadi, Ali
• Is Part Of: Journal of biomaterials science. Volume 34:Issue 3(2023)
• Page Start: 351
• Page End: 371
• Publication Date: 2023-02-11
• Subjects: Switchable polymers -- targeted drug delivery -- antibacterial activity -- biocompatible wound dressings -- electrospun scaffolds; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2022.2121591
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: This study investigated the release characteristics of curcumin (CUR)-loaded switchable poly(methyl methacrylate)- co -poly(N, N-diethylaminoethyl methacrylate) (PMMA- co -PDEAEMA) membranes following the application of various stimuli, as well as the platform's applicability in wound dressing and tissue engineering applications. The free-radical polymerization method was used to synthesize the PMMA- co -PDEAEMA copolymer. The drug-loaded nanofibrous membrane with electric potential (EP)-, CO2 -, and pH-responsive properties was developed by the electrospinning of PMMA- co -PDEAEMA and CUR. The resulted structure was characterized by a scanning electron microscope (SEM) coupled with X-ray energy dispersive spectroscopy and wide-angle X-ray scattering measurements. The release characteristics of the CUR-loaded wound covering were analyzed in various simulated environments at varying voltages, alternated CO2 /N2 gas bubbling, and at two different pH values; the results demonstrated high drug release controllability. Loaded CUR displayed high stability and better solubility compared with free CUR. The CUR-loaded tissue also exhibited high antibacterial activity against Escherichia coli and staphylococcus aureus bacteria. In addition, the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay depicted high biocompatibility of up to 95% in the CUR-loaded membrane. This platform could be a promising candidate for usage in tissue engineering and medical applications such as targeted drug delivery, biodetection, reversible cell capture-and-release systems, and biosensors.