Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. (7th February 2023)

• Record Type: Journal Article
• Authors: Clark-Corrigall, John; Myssina, Svetlana; Michaelis, Martin; Cinatl, Jindrich; Ahmed, Shafiq; Carr-Wilkinson, Jane
• Is Part Of: Cancer investigation. Volume 41:Number 2(2023)
• Page Start: 173
• Page End: 182
• Publication Date: 2023-02-07
• Subjects: LGR5 -- LRP6 -- WNT pathway -- neuroblastoma -- acquired drug resistance; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2136682
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Neuroblastoma (NB) is a pediatric solid cancer with high fatality, relapses, and acquired resistance to chemotherapy, that requires new therapeutic approaches to improve survival. LGR5 is a receptor that potentiates WNT/signaling pathway and has been reported to promote development and survival in several adult cancers. In this study we investigated LGR5 expression in a panel of NB cell lines with acquired resistance to vincristine or doxorubicin. We show LGR5-LRP6 cooperation with enhanced expression in drug resistant NB cell lines compared to parental cells, suggesting a role for LGR5 in the emergence of drug resistance, warranting further investigation