Rh(iii)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C–H activation. Issue 4 (3rd January 2023)

• Record Type: Journal Article
• Authors: Chen, Wenxi; Mao, Yan; Wang, Min; Ling, Fei; Li, Changchang; Chen, Zhangpei; Yao, Jinzhong
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 4(2023)
• Page Start: 775
• Page End: 782
• Publication Date: 2023-01-03
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob02001g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C–H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5, 1- a ]isoindoles is described. Abstract : A rhodium-catalyzed formal [4 + 1]-cyclization reaction of aryl substituted pyrazoles with cyclopropanols via C–H bond activation/cyclization processes to selectively construct a series of carbonyl functionalized pyrazolo[5, 1- a ]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C–H cleavage might be the rate-determining step in this transformation.