Syn-Elimination of glutamylated threonine in lanthipeptide biosynthesis. Issue 9 (10th January 2023)

• Record Type: Journal Article
• Authors: Sarksian, Raymond; Zhu, Lingyang; van der Donk, Wilfred A.
• Is Part Of: Chemical communications. Volume 59:Issue 9(2023)
• Page Start: 1165
• Page End: 1168
• Publication Date: 2023-01-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06345j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Formation of ( E )-dehydrobutyrine during lanthipeptide biosynthesis. Abstract : Methyllanthionine (MeLan) containing macrocycles are key structural features of lanthipeptides. They are formed typically by anti -elimination of l -Thr residues followed by cyclization of l -Cys residues onto the ( Z )-dehydrobutyrine (Dhb) intermediates. In this report we demonstrate that the biosynthesis of lanthipeptides containing the d - allo -l -MeLan macrocycle such as the morphogenetic lanthipeptide SapT proceeds through ( E )-Dhb intermediates formed by net syn -elimination of l -Thr.