Paget's disease of the breast: diagnosis and management. (2nd January 2023)

• Record Type: Journal Article
• Authors: Hudson-Phillips, Sarah; Cox, Kofi; Patel, Puja; Al Sarakbi, Wail
• Is Part Of: British journal of hospital medicine. Volume 84:Number 1(2023)
• Page Start: 1
• Page End: 8
• Publication Date: 2023-01-02
• Subjects: Breast cancer -- Breast surgery -- Paget's disease of the breast; Medicine -- Periodicals; Hospital care -- Periodicals; 610.5
• DOI: 10.12968/hmed.2022.0439
• Languages: English
• ISSNs: 1750-8460

Abstract

Abstract : Paget's disease of the breast typically affects postmenopausal women and is associated with an underlying malignancy. Skin changes are a common presenting symptom, as well as a lump, nipple discharge, pain and changes to the nipple shape. Imaging options include ultrasound for women under the age of 35 years or mammogram and ultrasound for women over the age of 40 years. The definitive diagnostic investigation is a tissue core biopsy. Cases are discussed by a multidisciplinary team to decide on the optimal management strategy. Management options are typically surgical and include breast-conserving surgery or mastectomy in addition to oncoplastic techniques. Sentinel lymph node biopsy is performed in all patients undergoing surgery. Adjuvant chemotherapy, radiotherapy or endocrine therapy can be used to treat concomitant invasive disease or ductal carcinoma in situ.