Longevity and reliability of chronic unit recordings using the Utah, intracortical multi-electrode arrays. (28th December 2021)

• Record Type: Journal Article
• Authors: Sponheim, Caleb; Papadourakis, Vasileios; Collinger, Jennifer L; Downey, John; Weiss, Jeffrey; Pentousi, Lida; Elliott, Kaisa; Hatsopoulos, Nicholas G.
• Is Part Of: Journal of neural engineering. Volume 18:Number 6(2021)
• Publication Date: 2021-12-28
• Subjects: electrode array reliability -- longevity -- chronic signal quality -- cortex -- non-human primate electrophysiology -- human electrophysiology; Neurosciences -- Periodicals; Biomedical engineering -- Periodicals; 612.8
• DOI: 10.1088/1741-2552/ac3eaf
• Languages: English
• ISSNs: 1741-2560

Abstract

Abstract: Objective. Microelectrode arrays are standard tools for conducting chronic electrophysiological experiments, allowing researchers to simultaneously record from large numbers of neurons. Specifically, Utah electrode arrays (UEAs) have been utilized by scientists in many species, including rodents, rhesus macaques, marmosets, and human participants. The field of clinical human brain-computer interfaces currently relies on the UEA as a number of research groups have clearance from the United States Federal Drug Administration (FDA) for this device through the investigational device exemption pathway. Despite its widespread usage in systems neuroscience, few studies have comprehensively evaluated the reliability and signal quality of the Utah array over long periods of time in a large dataset. Approach. We collected and analyzed over 6000 recorded datasets from various cortical areas spanning almost nine years of experiments, totaling 17 rhesus macaques ( Macaca mulatta ) and 2 human subjects, and 55 separate microelectrode Utah arrays. The scale of this dataset allowed us to evaluate the average life of these arrays, based primarily on the signal-to-noise ratio of each electrode over time. Main results. Using implants in primary motor, premotor, prefrontal, and somatosensory cortices, we found that the average lifespan of available recordings from UEAs was 622 days, although we provide several examples of these UEAs lasting over 1000 days and one up to 9 years; human implants were also shown to last longer than non-human primate implants. We also found that electrode length did not affect longevity and quality, but iridium oxide metallization on the electrode tip exhibited superior yield as compared to platinum metallization. Significance. Understanding longevity and reliability of microelectrode array recordings allows researchers to set expectations and plan experiments accordingly and maximize the amount of high-quality data gathered. Our results suggest that one can expect chronic unit recordings to last at least two years, with the possibility for arrays to last the better part of a decade.