3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property. (January 2023)

• Record Type: Journal Article
• Authors: Shao, Huifeng; Jing, Zhuoluo; Xia, Pengcheng; Zhang, Tao; Nian, Zhiheng; Liu, Wanshun; Zhu, Jiahua; Gong, Youping; Zhou, Rougang; He, Yong; Yao, Qingqiang
• Is Part Of: Materials & design. Volume 225(2023)
• Publication Date: 2023-01
• Subjects: 3D printing -- Magnesium-doped wollastonite -- Bioceramic scaffolds -- Anti-tumor property -- Nano-hydroxyapatite; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2022.111464
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: Customized magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with precise porous structures were fabricated by 3D printing and coating technique. Composite bioceramic scaffold with 15 μm coating thickness exhibited the highest mechanical properties. Nano-hydroxyapatite coating can effectively inhibite the proliferation of human osteosarcoma cells. Composite bioceramic scaffold had significantly enhanced osteogenic induction on Rat bone marrow stem cells. Abstract: It is still a major challenge to remove tumor cells and fill bone defects after tumor resection. Combined with the 3D printing technology, the composite bioceramics scaffolds were fabricated with interconnected porous magnesium-doped wollastonite (CSi-Mg) scaffolds as the architecture and nano-hydroxyapatite ( n -HA) as the surface. The influence of manufacturing process on the n -HA layer thickness and degradation performance, biological performance and anti-tumor performance of the composite scaffolds were investigated. The n -HA surface layer could effectively retard the degradation rate of CSi-Mg scaffolds and maintain high mechanical strength (over 90 MPa) after immersion in simulated body fluid for 3 weeks. Meanwhile, CSi-Mg/n-HA3 scaffold induced about 50 % of cell death for human osteosarcoma cells (MG-63) in vitro. CSi-Mg/ n -HAx (x = 1, 3) scaffolds could improve the osteogenic performance of Rat BMSC. These findings demonstrate that the bioceramic composite scaffold with high strength, good osteogenic performance and anti-tumor performance is promising for the treatment of tissue injury after resection of osteosarcoma.