Lost in space: design of experiments and scientific exploration in a Hogarth Universe. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Lendrem, Dennis W.; Lendrem, B. Clare; Woods, David; Rowland-Jones, Ruth; Burke, Matthew; Chatfield, Marion; Isaacs, John D.; Owen, Martin R.
• Is Part Of: Drug discovery today. Volume 20:Issue 11(2015)
• Page Start: 1365
• Page End: 1371
• Publication Date: 2015-11
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2015.09.015
• Languages: English
• ISSNs: 1359-6446

Abstract

Graphical abstract: Highlights: R&D technical problems give rise to complex, or Hogarth, problem spaces. Traditional methods of exploring such spaces are flawed. Design of experiments tools permit the efficient mapping of these spaces. The GSK Reaction Simulator gives scientists experience of working in such complex spaces. Abstract : A Hogarth, or 'wicked', universe is an irregular environment generating data to support erroneous beliefs. Here, we argue that development scientists often work in such a universe. We demonstrate that exploring these multidimensional spaces using small experiments guided by scientific intuition alone, gives rise to an illusion of validity and a misplaced confidence in that scientific intuition. By contrast, design of experiments (DOE) permits the efficient mapping of such complex, multidimensional spaces. We describe simulation tools that enable research scientists to explore these spaces in relative safety.