Duration of Cisplatin Excretion in Breast Milk. (November 2013)

• Record Type: Journal Article
• Authors: Hays, Karen E.; Ryu, Rachel J.; Swisher, Elizabeth M.; Reed, Eddie; McManus, Terry; Rybeck, Blanche; Petros, William P.; Hebert, Mary F.
• Is Part Of: Journal of human lactation. Volume 29:Number 4(2013)
• Page Start: 469
• Page End: 472
• Publication Date: 2013-11
• Subjects: breastfeeding -- breast milk -- cisplatin -- human milk; Breastfeeding -- Periodicals; Lactation -- Periodicals; 612.664
• DOI: 10.1177/0890334413479671
• Languages: English
• ISSNs: 0890-3344

Abstract

Cisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents. The authors found that platinum was undetectable in breast milk at 66 hours and beyond following a 70-mg dose of intravenous cisplatin. Relative infant dose of platinum was calculated to be between 0.29% and 0.40% of the maternal dose corrected for body weight. This case demonstrates minimal exposure to platinum via breast milk, following a single 70-mg intravenous dose of cisplatin.