The application of hierarchy MoS2 particles for NIR induced drug delivery towards liver cancer treatment. (28th October 2020)

• Record Type: Journal Article
• Authors: Wang, Kai; Li, Chengfang; Li, Yin; Wang, Jinjing; Ma, Aiqing
• Is Part Of: Materials research express. Volume 7:Number 10(2020)
• Publication Date: 2020-10-28
• Subjects: MoS2 particles -- near-infrared irradiation -- photothermal -- drug delivery -- doxorubicin -- 1-tetradecanol; Materials science -- Research -- Periodicals; Materials science -- Periodicals; 620.11
• DOI: 10.1088/2053-1591/abc21d
• Languages: English
• ISSNs: 2053-1591

Abstract

Abstract: This paper applied hierarchy MoS2 particles for near-infrared induced drug delivery towards liver cancer treatment. MoS2 particles were used as the photothermal responsive agent, 1-tetradecanol was used as the phase change material, doxorubicin was encapsulated into the particles, and MoS2 /1-tetradecanol@doxorubicin composite was synthesized. The drug release was tested under near-infrared irradiation. Within the MoS2 /1-tetradecanol@doxorubicin composite, the photothermal response of MoS2 to near-infrared facilitated the phase change of 1-tetradecanol and the release of doxorubicin. The release of doxorubicin could be regulated by both the MoS2 concentration and the irradiation power. The cytotoxicity study indicated that MoS2 /1-tetradecanol had negligible toxicity to the HepG2 cells, while MoS2 /1-tetradecanol@doxorubicin had more tumor-killing effects than free doxorubicin. This research showed that hierarchy MoS2 particles had the potential of delivering anti-tumor drugs through photothermal stimuli.