Resistance of Optogenetically Evoked Motor Function to Global Ischemia and Reperfusion in Mouse in Vivo. Issue 8 (August 2013)

• Record Type: Journal Article
• Authors: Xie, Yicheng; Chen, Shangbin; Anenberg, Eitan; Murphy, Timothy H
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 33:Issue 8(2013)
• Page Start: 1148
• Page End: 1152
• Publication Date: 2013-08
• Subjects: brain recovery -- cortical mapping -- electrophysiology -- global ischemia -- reperfusion; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2013.89
• Languages: English
• ISSNs: 0271-678X

Abstract

Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minute period of global ischemia. Our results suggest a differential sensitivity of sensory and motor systems to the effects of global ischemia and reperfusion that may have implications for rehabilitation.