Multiple-Capillary Measurement of RBC Speed, Flux, and Density with Optical Coherence Tomography. Issue 11 (November 2013)

• Record Type: Journal Article
• Authors: Lee, Jonghwan; Wu, Weicheng; Lesage, Frederic; Boas, David A
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 33:Issue 11(2013)
• Page Start: 1707
• Page End: 1710
• Publication Date: 2013-11
• Subjects: capillaries -- cerebral blood flow measurement -- cranial windows -- microscopy -- optical imaging; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2013.158
• Languages: English
• ISSNs: 0271-678X

Abstract

As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynamics over many capillaries at different depths at the same time.