Structural biology of ionotropic glutamate delta receptors and their crosstalk with metabotropic glutamate receptors. (15th September 2021)

• Record Type: Journal Article
• Authors: Burada, Ananth Prasad; Vinnakota, Rajesh; Lambolez, Bertrand; Tricoire, Ludovic; Kumar, Janesh
• Is Part Of: Neuropharmacology. Volume 196(2021)
• Publication Date: 2021-09-15
• Subjects: Delta receptors -- Ionotropic -- Metabotropic -- Synaptic plasticity -- Glutamate receptors -- CryoEM; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2021.108683
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: Enigmatic orphan glutamate delta receptors (GluD) are one of the four classes of the ionotropic glutamate receptors (iGluRs) that play key roles in synaptic transmission and plasticity. While members of other iGluR families viz AMPA, NMDA, and kainate receptors are gated by glutamate, the GluD receptors neither bind glutamate nor evoke ligand-induced currents upon binding of glycine and D-serine. Thus, the GluD receptors were considered to function as structural proteins that facilitate the formation, maturation, and maintenance of synapses in the hippocampus and cerebellum. Recent work has revealed that GluD receptors have extensive crosstalk with metabotropic glutamate receptors (mGlus) and are also gated by their activation. The latest development of a novel optopharamcological tool and the cryoEM structures of GluD receptors would help define the molecular and chemical basis of the GluD receptor's role in synaptic physiology. This article is part of the Neuropharmacology Special Issue on 'Glutamate Receptors – Orphan iGluRs'. Highlights: GluD receptors play key roles in synaptic transmission and plasticity. But the molecular underpinnings for their mechanisms remain obscure. Availability of optopharamcological tools and structures of GluDs would help define molecular and chemical basis of their roles at synapses. The functional crosstalk between metabotropic glutamate receptors and GluDs and their role in synaptic physiology are beginning to emerge.