A new insight into the lens: cytosolic PLAAT phospholipases degrade organelles to make the lens transparent. Issue 9 (2nd September 2021)

• Record Type: Journal Article
• Authors: Morishita, Hideaki; Eguchi, Tomoya; Mizushima, Noboru
• Is Part Of: Autophagy. Volume 17:Issue 9(2021)
• Page Start: 2645
• Page End: 2647
• Publication Date: 2021-09-02
• Subjects: Autophagy -- HRASLS -- lens -- mice -- organelle degradation -- phospholipase -- PLA2G16 -- PLAAT -- zebrafish; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2021.1950372
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: All membrane-bound organelles are degraded during the terminal differentiation of lens fiber cells. How these organelles are degraded has been a long-standing question in biology. We recently revealed that PLAAT (phospholipase A and acyltransferase)-family phospholipases degrade organelles in the lens independently of macroautophagy. Here, we discuss the mechanism and physiological relevance of this new mode of intracellular degradation.