Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy (Adv. Sci. 3/2023). Issue 3 (25th January 2023)

• Record Type: Journal Article
• Authors: Li, Ya‐Nan; Liang, Hong‐Wen; Zhang, Chun‐Lin; Qiu, Yan‐Mei; Wang, David; Wang, Hai‐Ling; Chen, An‐Qi; Hong, Can‐Dong; Wang, Lei; Wang, Hao; Hu, Bo
• Is Part Of: Advanced science. Volume 10:Issue 3(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-25
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202370012
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Smart Supramolecular Peptides In article number 2203351, Lei Wang, Hao Wang, Bo Hu, and co‐workers report the formulation of a smart supramolecular peptide (SSP) eye drop for diabetic retinopathy treatment that is effective via specifically identifying and capturing Semaphorin4D (Sema 4D), a strongly pro‐angiogenesis and exudates factor. The combination of SSP eye drop and anti‐vascular endothelial growth factor (VEGF) injection showed approximately two times better therapeutic effect over anti‐VEGF treatment alone. This work provides an alternative and effective method for noninvasive treatment for diabetic retinopathy.