Decreased antibody response to influenza vaccine with an enhanced antibody response to subsequent SARS‐CoV‐2 vaccination in patients with chronic hepatitis B virus infection. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: He, Taiyu; Ling, Ning; Zhang, Gaoli; Xiang, Dejuan; Hu, Peng; Peng, Mingli; Cai, Dachuan; Zhang, Dazhi; Chen, Min; Ren, Hong
• Is Part Of: Immunity, inflammation and disease. Volume 11:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-31
• Subjects: CHB -- cirrhosis -- influenza -- SARS‐CoV‐2 -- immune response; Immunology -- Periodicals; Immunity -- Periodicals; Inflammation -- Periodicals; 616.079
• DOI: 10.1002/iid3.759
• Languages: English
• ISSNs: 2050-4527

Abstract

Abstract: Introduction: Influenza or SARS‐CoV‐2 vaccination is especially recommended for people with underlying diseases. For the large number of patients with chronic hepatitis B virus infection (CHB), studies on their immune responses to these vaccines are still lacking. Methods: A total of 57 CHB patients and 19 healthy controls (HCs) receiving inactivated influenza vaccination were prospectively followed up. Influenza‐specific immunoglobulin G (IgG) antibodies (anti‐H1N1, anti‐H3N2, and anti‐B IgG), antibody‐secreting cells (ASCs), and circulating T follicular helper cells were assessed simultaneously. Eight CHB patients subsequently got inactivated SARS‐CoV‐2 vaccination during 1‐year follow‐up, and levels of serum antibodies against SARS‐CoV‐2 were further analyzed. Results: On day 28 after influenza vaccination, three influenza antibodies levels appeared to be lower in CHB patients than in HCs. And anti‐H1N1 IgG level was significantly decreased in cirrhotic patients ( p < .05). Anti‐H1N1 IgG levels (day 28) were positively correlated with ASC frequencies (day 7) ( p < .05), and negatively correlated with cirrhosis and hepatitis B surface antigen levels ( p < .05). Anti‐SARS‐CoV‐2 antibodies were higher in patients with influenza vaccination history than in patients without the history ( p < .05). Moreover, positive correlations existed between influenza vaccination history and anti‐SARS‐CoV‐2 antibody levels ( p < .01). Conclusions: CHB patients, especially those with cirrhosis, appeared to have a decreased antibody response to inactivated influenza vaccine. A history of inactivated influenza vaccination within 1 year before inactivated SARS‐CoV‐2 vaccination might induce stronger anti‐SARS‐CoV‐2 antibody response. Abstract : Antibody response to an inactivated influenza vaccine appears to be reduced in patients with CHB, especially in those with cirrhosis. A history of inactivated influenza vaccination within 1 year before inactivated SARS‐CoV‐2 vaccination might result in a stronger anti‐SARS‐CoV‐2 antibody response