Cataracts and Dupuytren Disease: A Case Report and Review of the Literature. Issue 1 (January 2013)

• Record Type: Journal Article
• Authors: Cutolo, Carlo A.; Lombardo, Sara; Vercellin, Alice C. Verticchio; Bertone, Chiara; De Amici, Mara; Antoniazzi, Elena; Milano, Giovanni
• Is Part Of: European journal of ophthalmology. Volume 23:Issue 1(2013)
• Page Start: 135
• Page End: 137
• Publication Date: 2013-01
• Subjects: Cataract -- Dupuytren -- TGF-β; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; 617.7005
• DOI: 10.5301/ejo.5000208
• Languages: English
• ISSNs: 1120-6721

Abstract

Purpose: Dupuytren disease is an inherited proliferative and progressive connective disease. Ectopic disease may, however, be located distant from the palmar fascia. Methods: Case report and review of the literature. Results: We describe a case of symmetric bilateral posterior subcapsular cataracts associated with symmetric bilateral Dupuytren disease and symmetric bilateral Ledderhose disease in a 56-year-old Caucasian man. His medical history was negative for glucocorticoids intake, diabetes, and exposure to radiation. Serum transforming growth factor β (TGF-β)1 concentration has been evaluated and was found to be almost double compared to the controls. Conclusions: We speculate that the TGF-β plays an important role for ocular and connective tissue disorders.