Human leucocyte antigen – G gene polymorphism in laryngeal squamous cell carcinoma patients in Mansoura University Hospitals. Issue 1 (1st January 2021) - Barakat, Ghada
ABSTRACT: This study aimed to detect the genetic association of HLA-G gene polymorphism with LSCC. It was a comparative study estimating the prevalence of both HLA-G 14-bp insertion versus deletion polymorphism and HLA-G*01:05 N null allele using PCR-RFLP. HLA-G 14-bp deletion allele was highly recorded in patients with LSCC (63.0%) whereas insertion allele (37.0%) was lower. The −14/-14 and −14/+14 genotypes were significantly higher in LSCC cases whereas +14/+14 genotype was not. HLA-G*01:05 N null allele was found in 39 LSCC cases (43.8%) and 47 control (52.8%), (p = 0.23). Distribution of studied alleles and genotypes showed no significant correlation to the clinic-pathological features of included cases. There was a significant association between HLA-G 14-bp deletion allele (versus insertion allele) and the risk of LSCC but no clear association between null allele and occurrence of LSCC was detected.