Severe Adams-Oliver Syndrome after Maternal COVID-19 Infection Could Be Another Effect of the SARS-CoV-2 Inflammatory Storm? Case Report. (2nd January 2023)

• Record Type: Journal Article
• Authors: Okido, Marcos Masaru; Ragazini, Conrado Savio; Duarte, Geraldo; Coutinho, Conrado Milani; Marcolin, Alessandra Cristina
• Is Part Of: Fetal and pediatric pathology. Volume 42:Number 1(2023)
• Page Start: 131
• Page End: 136
• Publication Date: 2023-01-02
• Subjects: Adams-Oliver syndrome -- COVID-19 infection -- ultrasound -- prenatal diagnosis; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2022.2064018
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background . Adams-Oliver syndrome is a congenital disease whose main findings are aplasia cutis congenita of the scalp and terminal transverse limb defects . The pathogenesis is unknown, but it is postulated that ischemic events in susceptible tissues cause the lesions in the embryonic period. Case report . We present a newborn with a severe phenotype of Adams-Oliver syndrome. The infant's mother had a SARS-CoV-2 infection in the first trimester of pregnancy. Prenatal ultrasound indicates a probable worsening of the disease after the first trimester. Conclusion. This study shows a previously unpublished severe AOS phenotype in a term newborn. There are some signs that the disease could have progressed beyond the first trimester, either spontaneously or by the inflammatory mechanisms of SARS-CoV-2.