Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: A cross-sectional study. (February 2021)

• Record Type: Journal Article
• Authors: Isola, Gaetano; Lo Giudice, Antonino; Polizzi, Alessandro; Alibrandi, Angela; Murabito, Paolo; Indelicato, Francesco
• Is Part Of: Archives of oral biology. Volume 122(2021)
• Publication Date: 2021-02
• Subjects: Gingival health -- Periodontitis -- Saliva -- Interleukin-6 -- Clinical study; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2020.104997
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: PT patients had significant higher serum and salivary IL-6. There was a significant progressive increase in salivary IL-6 with a proportional extent level of PT and tooth loss. Salivary IL-6 was demonstrated a valid salivary predictor of gingival health. Abstract: Objective: The aim of this study was to analyze and identify the association among salivary interleukin-6 (IL-6) levels and periodontitis (PT) and to determine the significant trend of this association in PT patients. Study design: For the present study, 49 patients with PT and 47 healthy subjects (HS) were enrolled and assessed for clinical parameters, blood samples and salivary IL-6 analyses. Clinical differences among groups were recorded and evaluated. The Spearman Correlation and the Jonckheere-Terpstra Test were applied in order to assess the interdependence between salivary IL-6 and PT. Results: Patients in the PT group had significantly higher median salivary IL-6 levels [195.4 (184.6–205.9 pg/mL)] compared to the HS group [101.9 (89.5–115.4 pg/mL) (p < 0.001). Salivary IL-6 levels were negatively correlated with C-reactive protein, with the number of teeth and with clinical attachment loss (CAL), probing pocket depth (PPD), and bleeding sites (FMBS) (p < 0.001). Furthermore, in patients with PT, salivary IL-6 levels were inversely associated (P-trend) with the number of teeth (p < 0.001), and directly associated with the proportional extent of PT (CAL, p = 0.006; PPD, p = 0.009; FMBS, p < 0.001). Conclusions: The results of this study showed that PT patients presented significant higher salivary IL-6 levels compared to HS. Moreover, in the analyzed sample a significant p-trend among PT, tooth loss and increased salivary IL-6 levels was found.