Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing. (15th May 2020)

• Record Type: Journal Article
• Authors: Ma, Mengsi; Zhong, Yalan; Jiang, Xulin
• Is Part Of: Carbohydrate polymers. Volume 236(2020)
• Publication Date: 2020-05-15
• Subjects: Chitin (PubChem CID: 6857375) -- Propylene oxide (PubChem CID: 146261) -- Urea (PubChem CID: 1176) -- Sodium hydroxide (PubChem CID: 14798) -- Lysozyme (PubChem CID: 16129749) -- Iron trichloride hexahydrate (PubChem CID: 16211236) -- Tannic acid (PubChem CID: 16129778); Injectable hydrogel -- Thermogel -- Hydroxypropyl chitin -- Tannic acid -- Antibacterial hydrogel -- Wound dressing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116096
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Thermo-/pH-sensitive hydroxypropyl chitin/tannic acid/ferric ion hydrogel developed. The composite hydrogel can be easily injected to cover irregular wounds. The hydrogel has good biocompatibility and prolonged antibacterial activity. The antibacterial composite hydrogel could accelerate wound healing without scars. Abstract: Polysaccharide hydrogels have been widely used as wound dressings because of their biocompatibility and ability to provide moist environment for wound healing. However, bacterial infection often delays the healing process. Herein, a novel thermosensitive and pH-sensitive hydroxypropyl chitin/tannic acid/ferric ion (HPCH/TA/Fe) composite hydrogel was fabricated by a simple assembly. The pre-cooled hydrogel precursor solution can be injected onto the irregular wound area and gel rapidly at physiological temperature. The TA not only acted as a crosslinker to enhance mechanical properties of the hydrogel, but also as an antibacterial agent which could be sustainably released in response to the acidic environment. The composite hydrogel showed excellent broad-spectrum antibacterial activity up to 7 days with negligible cytotoxicity. Moreover, the hydrogel can inhibit bacterial infection and accelerate the wound healing process without scars in the mouse experiment. These results indicate the potential application of this composite hydrogel for the infected wound healing.