Transcription Factor HES-1: How Is the Expression of This Transcriptional Factor in Paucibacillary Leprosy Patients?. (7th February 2023)

• Record Type: Journal Article
• Authors: Serrano-Coll, Héctor; Ospina-Gómez, Juan Pablo; Salamanca, Carolina; Restrepo, Lina; Berbeo, Katerine; Olarte, Graciela; Cardona-Castro, Nora
• Is Part Of: American journal of dermatopathology. Volume 45:Number 2(2023)
• Page Start: 99
• Page End: 106
• Publication Date: 2023-02-07
• Subjects: notch signaling pathway -- public health -- Mycobacterium leprae -- neglected diseases -- skin; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000002335
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract : Supplemental Digital Content is Available in the Text. Abstract : Introduction: Leprosy is an ancient and chronic infectious disease caused by 2 mycobacteria ( Mycobacterium leprae and Mycobacterium lepromatosis ). Recently, our research group observed that HES-1, an innate cellular component of the Notch signaling pathway, is related to the pathogenesis of leprosy. Therefore, it could be helpful in its detection. Objective: To determine the expression of HES-1 in the skin of patients with paucibacillary (PB) leprosy. Methods: A cross-sectional, descriptive, observational study was conducted. Forty-five skin samples from patients with leprosy were evaluated (30 samples from MB leprosy and 15 from PB leprosy) using immunohistochemistry of HES-1 and S-100. Results: PB leprosy biopsies revealed a reduction of HES-1 in 66.7% of the epidermis, 80% of the eccrine glands, and 62.5% of the hair follicles of these patients, with statistical differences in the control group ( P < 0.0001). Besides, HES-1 showed similar utility to S-100 immunostaining in detecting the MB and PB leprosy. Conclusions: HES-1 is a transcriptional factor also reduced in PB patients' epidermis and skin appendages. Finally, our data show that HES-1 could be a biomarker in diagnosing PB and MB leprosy.