Delineating Plasmodium liver infection across space and time. Issue 2 (February 2023)

• Record Type: Journal Article
• Authors: Hildebrandt, Franziska; Ankarklev, Johan; Matuschewski, Kai
• Is Part Of: Trends in parasitology. Volume 39:Issue 2(2023)
• Page Start: 80
• Page End: 82
• Publication Date: 2023-02
• Subjects: Plasmodium -- liver zonation -- spatiotemporal transcriptomic analysis -- single-cell RNA sequencing -- single-molecule fluorescence in situ hybridization -- host–parasite interactions; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2022.12.005
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract: The liver is a major entry point and gatekeeper for invasive pathogens. However, high-resolution, spatiotemporal transcriptomic analysis of host–pathogen interactions has remained challenging. Afriat et al . have deconvoluted Plasmodium berghei liver-stage maturation at an unprecedented scale and discovered molecular signatures of heterogeneity during pre-erythrocytic development of malarial parasites.