Association of Antiribosomal P Antibody with Neurological and Systemic Manifestations in Patients with Systemic Lupus Erythematosus in Southwestern Colombia. (4th June 2021)

• Record Type: Journal Article
• Authors: Marín, Juan-David; Vargas, Sthephany; Ruiz-Ordoñez, Ingrid; Posso-Osorio, Iván; Nieto-Aristizábal, Ivana; Barrera, María Claudia; Ríos-Serna, Lady J; Tobón, Gabriel J
• Is Part Of: Journal of applied laboratory medicine. Volume 7:Number 1(2022)
• Page Start: 3
• Page End: 11
• Publication Date: 2021-06-04
• Subjects: anti-P antibody -- autoantibodies -- autoimmune disease -- biomarkers -- systemic lupus erythematosus; Clinical chemistry -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.0756
• DOI: 10.1093/jalm/jfab045
• Languages: English
• ISSNs: 2576-9456

Abstract

Abstract: Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous pathogenesis, various clinical manifestations, and a broad spectrum of autoantibodies which recognize different cellular components. This study examines the clinical significance and serological associations of serum antiribosomal P antibodies (anti-P) derived from SLE patients in a population from southwestern Colombia. Methods: We performed a cross-sectional study of 66 SLE patients. Serum antiribosomal P0 autoantibodies were detected by line immunoassay using the ANA-LIA MAXX kit and processed on the automated HumaBlot 44 FA system (Human Diagnostics, Germany). Results: Of the 66 SLE patients included in the study, 17 patients (25.76%) showed anti-P positivity by line immunoassay (IA), 47 (71.21%) were negative, and results from 2 patients were indeterminate. We did not find an association with neuropsychiatric SLE (NPSLE), renal, or hepatic disorders ( P > 0.05). Laboratory findings indicated that anti-P positivity was significantly associated to anti-Smith ( P = 0.001), anti-Ro60/SSA ( P = 0.046), and anti-dsDNA antibodies ( P = 0.034), the latter being true only when performed using indirect immunofluorescence (IIF). Conclusion: The anti-P antibodies are not associated with clinical manifestations such as NPSLE, lupus nephritis, or hepatic involvement in the southwest Colombian SLE population. Moreover, we confirmed previously reported association between anti-P antibody, serum anti-dsDNA, and anti-Smith.