Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive. (15th June 2018)

• Record Type: Journal Article
• Authors: Xu, Yiwen; Liang, Kai; Ullah, Wajeeh; Ji, Yali; Ma, Jinghong
• Is Part Of: Carbohydrate polymers. Volume 190(2018)
• Page Start: 324
• Page End: 330
• Publication Date: 2018-06-15
• Subjects: Chitin nanocrystal -- Tissue adhesive -- Dopamine -- Citrate; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.03.005
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Chitin nanocrystal was creatively used to improve the wet adhesion property of tissue adhesive. Homogeneous nanocomposite adhesives were facilely prepared by simple aqueous blending. Chitin nanocrystal endowed the adhesive with extra crosslinks to enhance the bulk cohesion property. Macroscopic wet adhesion performance was considerably improved with increasing ChiNC content. Abstract: Chitin nanocrystal (ChiNC) with its good biodegradability and biocompatibility as well as rod-like structure characteristic has become one of excellent nanofillers to enhance mechanical properties and bioactivity of biomedical polymers. For further extending its application fields, here, we dispersed ChiNC into a recently synthesized citrate-based tissue adhesive (POEC-d) and explored its effects on the adhesion and cytocompatibility of the adhesive. POEC-d, a mussel-inspired wet adhesive, was prepared by a one-pot melt polycondensation of 1, 8-octanediol, poly(ethylene oxide) (PEO), citric acid (CA) and dopamine (DA). The good water-solubility of POEC-d allowed facilely blending ChiNC and POEC-d to ultimately acquire POEC-d/ChiNC nanocomposite adhesives. The results showed the ChiNCs were finely dispersed in the POEC-d matrix and endowed the adhesive with extra crosslinks to enhance the bulk cohesion property. Synchronously, the lap-shear adhesion strengths measured by bonding wet porcine skins considerably improved with increasing the ChiNC content. In addition, the POEC-d/ChiNC nanocomposite adhesives exhibited lower swelling ratio as compared to the POEC-d adhesive as well as good cytocompatibility, revealing their superior applicability in soft-tissue adhesion.