X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice. Issue 3 (December 2018)

• Record Type: Journal Article
• Authors: Montay-Gruel, Pierre; Bouchet, Audrey; Jaccard, Maud; Patin, David; Serduc, Raphael; Aim, Warren; Petersson, Kristoffer; Petit, Benoit; Bailat, Claude; Bourhis, Jean; Bräuer-Krisch, Elke; Vozenin, Marie-Catherine
• Is Part Of: Radiotherapy and oncology. Volume 129:Issue 3(2018)
• Page Start: 582
• Page End: 588
• Publication Date: 2018-12
• Subjects: Ultra-high dose-rate X-ray radiation -- Synchrotron radiation -- Cognitive impairment -- Radiation-induced brain injury; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2018.08.016
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.