Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study. (1st January 2021)

• Record Type: Journal Article
• Authors: Zhong, Li; Wu, Yuting; Gao, Jinghua; Zhang, Jinxia; Xie, Qifeng; He, Huang; Ji, Jingjing; Liu, Zheying; Wang, Conglin; Liu, Zhifeng
• Is Part Of: Annals of medicine. Volume 53:Number 1(2021)
• Page Start: 770
• Page End: 776
• Publication Date: 2021-01-01
• Subjects: COVID-19 -- hypertension -- clinical characteristics -- mortality -- age; Medicine -- Periodicals; 610
• DOI: 10.1080/07853890.2021.1931957
• Languages: English
• ISSNs: 0785-3890

Abstract

Abstract: Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available. Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A total of 983 patients with COVID-19 (female, 48%; male, 52%) were enrolled. Significantly higher odds of 60-day mortality ( p = .017) were observed in the hypertensive group. In the hypertensive group, even after adjustment in multivariate analysis, the subgroup of patients 70 years old and older had higher 28-day mortality and total 60-day mortality rates than the other age subgroups (both p < .05). A total of 297 (89%) COVID-19 patients with hypertension survived, and 35 (11%) died. In addition, compared with hypertensive patients who survived COVID-19, non-survivors had more pre-existing conditions, including cardiovascular diseases and stroke, higher blood pressure on admission, more severe inflammation, and more liver and kidney damage. Conclusion: Hypertension does not affect the outcome of COVID-19, which is different than the conclusions drawn in other studies. However, the 28-day mortality and total 60-day mortality rates of hypertensive patients (age ≥ 70) with COVID-19 were significantly elevated, and compared with the group of survivors, non-surviving COVID-19 patients with hypertension were older, had more basic diseases and had a more severe clinical condition.