The neurodevelopmental role of dopaminergic signaling in neurological disorders. (10th January 2021)

• Record Type: Journal Article
• Authors: Cai, Yunyun; Xing, Lingyan; Yang, Tuo; Chai, Rui; Wang, Jiaqi; Bao, Jingyin; Shen, Weixing; Ding, Sujun; Chen, Gang
• Is Part Of: Neuroscience letters. Volume 741(2021)
• Publication Date: 2021-01-10
• Subjects: Dopaminergic signalling -- Brain development -- Mental disorders; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2020.135540
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Dysfunction of dopaminergic signaling may lead to a series of developmental disorders. DA regulates physiological functions by projecting to a wide range of brain regions. DA influences the pathogenesis of several diseases related to brain development. Abstract: Dopamine (DA), a critical neurotransmitter of both the central and peripheral nerve system, plays important roles in a series of biological processes. Dysfunction of dopaminergic signalling may lead to a series of developmental disorders, including attention deficit/hyperactivity disorder, autism and schizophrenia. However, the exact roles of dopaminergic signalling in these diseases are far from fully understood. We analyse the roles of dopaminergic signalling in multiple physiological and pathological processes, focusing on brain development and related disorders. By summarizing current research in this area, we provide guidance for future studies. This review seeks to deepen our understanding of dopaminergic signalling in developmental disorders, which may offer clues for developing more effective therapeutic drugs.