Chitosan-cellulose hydrogel conjugated with L-histidine and zinc oxide nanoparticles for sustained drug delivery: Kinetics and in-vitro biological studies. (15th May 2020)

• Record Type: Journal Article
• Authors: George, Dhanya; Maheswari, P. Uma; Begum, K.M. Meera Sheriffa
• Is Part Of: Carbohydrate polymers. Volume 236(2020)
• Publication Date: 2020-05-15
• Subjects: L-Histidine - chitosan -- Cellulose crosslinker -- Nanohybrid hydrogel -- Drug delivery -- Antimicrobial -- Anticancer activity; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116101
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Biomass derived Dialdehyde cellulose crosslinked nanohybrid hydrogel. L-Histidine conjugation enhanced the carrier stability aiding sustained drug delivery. ZNPs embedment in hydrogel improved drug loading and release properties. Kinetic models evinced a non-Fickian diffusion controlled mechanism. Synergic effect on antimicrobial activity and anticancer activity was validated. Abstract: Functionalised nanohybrid hydrogel using L-Histidine (HIS) conjugated chitosan, phyto-synthesised zinc oxide nanoparticles (ZNPs) and dialdehyde cellulose (DAC) was formulated as a sustained drug delivery carrier for the polyphenol drugs – Naringenin (NRG), Quercetin (QE) and Curcumin (CUR). A maximum loading efficiency of 90.55 %, 92.84 % and 89.89 %, respectively were optimised for NRG, QE and CUR in the hybrid hydrogel. The maximum drug release was favoured for the optimum drug loading and at pH-5. HIS-chitosan conjugation stabilised the hydrogel and enabled a sustained drug delivery. Drug release kinetics predicted a non-Fickian diffusion-based mechanism along with polymer erosion. Prominent antimicrobial activity against Staphylococcus aureus and Trichophyton rubrum strains were predicted to evolve based on the synergic formulation. Significant biocompatibility towards L929 cells revealed their support for normal cell survival. Anticancer studies towards A431 cells exhibited excellent cytotoxicity with a 15 to 30-fold increase using the hybrid carrier, compared to the free polyphenol drugs.