Construction of an environmentally friendly octenylsuccinic anhydride modified pH-sensitive chitosan nanoparticle drug delivery system to alleviate inflammation and oxidative stress. (15th May 2020)

• Record Type: Journal Article
• Authors: Yu, Zhenjing; Ma, Lina; Ye, Shujuan; Li, Ganggang; Zhang, Mengmeng
• Is Part Of: Carbohydrate polymers. Volume 236(2020)
• Publication Date: 2020-05-15
• Subjects: Chitosan -- Octenylsuccinic anhydride -- pH-sensitivity -- Nanoparticle drug delivery system -- Anti-inflammatory -- Antioxidant; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.115972
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Octenylsuccinic anhydride modified chitosan (OSA-CS) nanoparticles were prepared. OSA-modified CS showed good solubility at physiological pH. OSA-CS nanoparticles exhibited pH-responsive drug release in acidic environments. Nanoparticles displayed excellent biocompatibility and high cellular uptake in vitro . Drug-load NPs improved anti-inflammatory and antioxidant properties of the system. Abstract: An environmentally friendly octenylsuccinic anhydride modified pH-sensitive chitosan-octenylsuccinic anhydride (OSA-CS) was synthesized. The critical micelle concentration (CMC) of the modified chitosan was 27 μg/mL, the graft polymers can form solubilized curcumin (CUR) and quercetin (QUE) nanoparticles. The drug-loaded nanoparticles had high encapsulation efficiency and drug loading content, the self-assembly of graft polymers formed spherical uniform nanoparticles with an approximate diameter of 150–180 nm. The nanoparticles were stable under storage conditions and in serum. The results revealed that OSA-CS exhibited excellent biocompatibility, no cytotoxicity. Additionally, the results of pH sensitivity and drug release experiments showed that the nanoparticles were highly sensitive to weakly acidic conditions (pH 6.0) and showed a faster release rate, while they were reasonably stable at physiological conditions (pH 7.4). The drug-loaded nanoparticles exhibited higher cellular uptake in vitro, and exhibited stronger anti-inflammatory and antioxidant efficacy. Therefore, OSA-CS-based nanoparticles are a promising hydrophobic drug delivery system for pH-response targeting therapy.