Surface functionalization of chitosan as a coating material for orthopaedic applications: A comprehensive review. (1st March 2021)

• Record Type: Journal Article
• Authors: Kumari, Suman; Tiyyagura, Hanuma Reddy; Pottathara, Yasir Beeran; Sadasivuni, Kishor Kumar; Ponnamma, Deepalekshmi; Douglas, Timothy E.L.; Skirtach, Andre G.; Mohan, M.K.
• Is Part Of: Carbohydrate polymers. Volume 255(2021)
• Publication Date: 2021-03-01
• Subjects: γ-PGA poly (γ-glutamic acid) -- n-Ag silver nanoparticle -- n-Au gold nanoparticles -- nBG nano-bioactive glass -- nHAp nano-hydroxyapatite -- Ag+ silver ion -- Ag silver -- Alg alginate -- Au gold -- AA acetic Acid -- AC-EPD alternative current electrophoretic deposition -- ALP alkaline phosphatase activity -- AZ91 magnesium alloy -- AZ91D magnesium alloy with small amount of iron -- BDG beta-1, 3/1, 6-d-glucan -- BG bio glass -- Ca calcium -- CaO2 calcium dioxide -- Ca3(PO4)2 calcium Phosphate -- Cr chromium -- C-CS carbooxymethyl Chitoan -- C-Hap carbonated hydroxyapatite coatings -- C-MWCNT carboxy multiwalled carbon nanotubes -- CA cellulose acetate -- Collagen coll -- CNT carbon nanotubes -- CS chitosan -- CVD chemical vapor deposition -- DA degree of acetylation -- DC-EPD direct current electrophoretic deposition -- DI deionized water -- DLA ethylene dilinoleate -- EPD electrophoretic deposition -- Gel gelatin -- GO graphene oxide -- GS gentamicin sulphate -- HA hyaluronic acid -- HAp hydroxyapatite -- HNT halloysite Nanotubes -- ITO indium tin oxide -- LBL layer-by-layer -- LP laponite -- mAb monoclonal antibodies -- M-HAp mineralized hydroxyapatite -- MAO Microarc oxidized -- MW-CNT multi-walled carbon nanotubes -- NiTi nickel-titanium shape memory alloy -- P phosphorous -- Pt platinum -- PBS phosphate buffer solution -- PC polycarbonate -- PDA poly dopamine -- PE polyethylene -- PEI poly(ethylene imine) -- PET poly(ethylene terephthalate) -- PVA poly vinyl alcohol -- PVP poly (vinyl pyrollidone) -- Rp polarization resistance -- Se selenium -- Si silicon -- Sr strontium -- SrO strontium Oxide -- SA sodium alginate -- SBF simulated body fluid -- SCE saturated calomel electrode -- SEM scanning electron microscope -- SMA shape memory alloy -- SS stainless steel -- Ti cp-titanium -- Ti-6Al-7Nb titanium-6aluminum-7niobium -- Ti-6Al-4V Ti-6 aluminum-4vanadium -- Ti-24Nb-2Zr titanium-24niobium-2zirconium -- TNT titanium nanotubes -- Zn zinc -- VEGF vascular endothelial growth factor -- ZnO zinc oxide -- W wollastonite; Chitosan -- Electrophoretic deposition -- Biomaterials -- Titanium alloys; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.117487
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Recent progress related to the surface modification of biomedical implant material, i.e. CS-based coatings is reviewed. CS- based coatings result in better cell adhesion, spreading, proliferation and bioactivity etc. Improved mineralisation was achieved by incorporating inorganic particles (eg. CaP, HaP, BG) into the CS coatings. Abstract: Metallic implants have dominated the biomedical implant industries for the past century for load-bearing applications, while the polymeric implants have shown great promise for tissue engineering applications. The surface properties of such implants are critical as the interaction of implant surfaces, and the body tissues may lead to unfavourable reactions. Desired implant properties are biocompatibility, corrosion resistance, and antibacterial activity. A polymer coating is an efficient and economical way to produce such surfaces. A lot of research has been carried out on chitosan (CS)-modified metallic and polymer scaffolds in the last decade. Different methods such as electrophoretic deposition, sol-gel methods, dip coating and spin coating, electrospinning, etc . have been utilized to produce CS coatings. However, a systematic review of chitosan coatings on scaffolds focussing on widely employed techniques is lacking. This review surveys literature concerning the current status of orthopaedic applications of CS for the purpose of coatings. In this review, the various preparation methods of coating, and the role of the surface functionalities in determining the efficiency of coatings are discussed. Effect of nanoparticle additions on the polymeric interfaces and in regulating the properties of surface coatings are also investigated in detail.