Anti-depression effect and mechanism of Suanzaoren Decoction on mice with depression. Issue 2 (March 2021)

• Record Type: Journal Article
• Authors: Zhang, Huan; Ren, Yumei; Lv, Meiqi; Xie, Mengting; Wang, Kai; Yang, Mengjie; Lv, Chengqi; Li, Xiaobing
• Is Part Of: IOP conference series. Volume 714:Issue 2(2021)
• Publication Date: 2021-03
• Subjects: Suanzaoren Decoction -- Reserpine -- Depression -- Norepinephrine, -- Dopamine; Earth sciences -- Periodicals; Environmental sciences -- Congresses; Environmental sciences -- Periodicals; 550.5
• DOI: 10.1088/1755-1315/714/2/022065
• Languages: English
• ISSNs: 1755-1307

Abstract

Abstract: Objective: To study the therapeutic effect and mechanism of Suanzaoren Decoction on mice with depression. Methods: A model of depression was prepared by chronic unpredictable stimulation and reserpine induction. Behavioral tests, determination of norepinephrine and dopamine were performed. Results: The behavioral indicators of the model group were reduced, and the expression of norepinephrine and dopamine was decreased. Conclusion: Suanzaoren Decoction has an effect on the increase of serum norepinephrine and dopamine content, indicating that the jujube seed Soup has a certain effect on depression.