Dietary supplementation with fructooligosaccharides ameliorates allergy development following DEHP exposure in mice. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Yasuda, Akiko; Inoue, Ken-ichiro; Sanbongi, Chiaki; Suzuki, Wakako; Takano, Hirohisa
• Is Part Of: Food and agricultural immunology. Volume 32:Issue 1(2021)
• Page Start: 419
• Page End: 424
• Publication Date: 2021-01-01
• Subjects: Fructooligosaccharides -- ovalbumin -- DEHP -- allergic inflammation -- peritoneal lavage -- KC -- IL-5 -- eotaxin; Immunochemistry -- Periodicals; Food -- Analysis -- Periodicals; Immunoassay -- Periodicals; 616.079
• DOI: 10.1080/09540105.2021.1952934
• Languages: English
• ISSNs: 0954-0105

Abstract

ABSTRACT: Fructooligosaccharides (FOS), a prebiotic supplement, can enhance immunological responses, probably through regulation of gastrointestinal microflora. On the other hand, some environmental pollutants have adjuvanticity against allergic reactions/diseases. The purpose of this study was to evaluate the effects of dietary supplementation with FOS on a murine model of enhanced ovalbumin (OVA)-related allergic peritonitis induced by di-(2-ethylhexyl) phthalate (DEHP). C3H/HeN mice were intraperitoneally administered OVA and DEHP, and fed a diet containing 2.5% FOS. Thereafter, several parameters were evaluated. Supplementation with FOS alleviated OVA plus DEHP-related peritoneal inflammation characterized by infiltration of polymorphonuclear leukocytes including neutrophils in the peritoneal cavity. Also, FOS administration declined the number of mast cells of OVA + DEHP treated mice. FOS suppressed the elevated protein level of interleukin-5, eotaxin, and keratinocyte-derived chemoattractant, in the peritoneal lavage fluids. Our results suggest that dietary supplementation with FOS can prevent or ameliorate enhanced allergic peritoneal inflammation induced by DEHP.