Studies on Development and Characterization of Biomaterials for Drug Delivery. Issue 1 (December 2020)

• Record Type: Journal Article
• Authors: Agrawal, Manoj Kumar; Sharma, Vikash Kumar
• Is Part Of: IOP conference series. Volume 988:Issue 1(2020)
• Publication Date: 2020-12
• Subjects: Poly vinyl alcohol -- Nanofibres -- Electrospinning -- Transdermal drug delivery -- Residronate sodium; Materials science -- Periodicals; 620.1105
• DOI: 10.1088/1757-899X/988/1/012068
• Languages: English
• ISSNs: 1757-8981

Abstract

Abstract: Although there are many methods used 10 synthesis nanofibers such as drawing, template Synthesis, phase separation, self assembly, and electro spinning. In these techniques, electrospinning is a manifold method to move polymers into continuous fibers with diameters within range of a few micrometers to a few nanometers. Poly Vinyl Alcohol (PVA) is a popular hydrogel polymers. Because of its good water permeability, biocompatibility, non-toxicity and speciallyelectro spinnability it is easily sustained release of the transdermal drug delivery. The nanoparticle was prepared to reduce hypertension using Residronate sodium drug incorporated to PVA. The Electrospinning method was used PVA solution mixed with Residronate sodium to form the drug loaded electro spun PVA nanofibers. These nano fibers was characterized by Scanning electron microscopy (SEM), UV-Visible spectroscopy analysis, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction method (XRD), and Thermo gravimetric analysis (TGA). In vitro drug release at different time interval and different pH was analysed using acetate buffer method.