The potential utility of liposomes for Neisseria vaccines. (3rd October 2021)

• Record Type: Journal Article
• Authors: Christodoulides, Myron; Humbert, Maria Victoria; Heckels, John E
• Is Part Of: Expert review of vaccines. Volume 20:Number 10(2021)
• Page Start: 1235
• Page End: 1256
• Publication Date: 2021-10-03
• Subjects: Antigen/adjuvant delivery -- antimicrobials -- liposomes -- nanoparticles -- Neisseria meningitidis -- Neisseria gonorrhoeae -- recombinant proteins -- vaccine -- outer membrane; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1080/14760584.2021.1981865
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: Introduction: Species of the genus Neisseria are important global pathogens. Neisseria gonorrhoeae (gonococcus) causes the sexually transmitted disease gonorrhea and Neisseria meningitidis (meningococcus) causes meningitis and sepsis. Liposomes are self-assembled spheres of phospholipid bilayers enclosing a central aqueous space, and they have attracted much interest and use as a delivery vehicle for Neisseria vaccine antigens. Areas covered: A brief background on Neisseria infections and the success of licensed meningococcal vaccines are provided. The absence of a gonococcal vaccine is highlighted. The use of liposomes for delivering Neisseria antigens and adjuvants, for the purposes of generating specific immune responses, is reviewed. The use of other lipid-based systems for antigen and adjuvant delivery is examined briefly. Expert opinion: With renewed interest in developing a gonococcal vaccine, liposomes remain an attractive option for delivering antigens. The discipline of nanotechnology provides additional nanoparticle-based options for gonococcal vaccine development. Future work would be needed to tailor the composition of liposomes and other nanoparticles to the specific vaccine antigen(s), in order to generate optimal anti-gonococcal immune responses. The potential use of liposomes and other nanoparticles to deliver anti-gonococcal compounds to treat infections also should be explored further.