Contact Allergy to Two Aluminum Salts in Consecutively Patch-Tested Dermatitis Patients. Issue 1 (9th September 2021)

• Record Type: Journal Article
• Authors: Siemund, Ingrid; Dahlin, Jakob; Hindsén, Monica; Zimerson, Erik; Antelmi, Annarita; Hamnerius, Nils; Hauksson, Inese; Isaksson, Marléne; Pontén, Ann; Mowitz, Martin; Svedman, Cecilia; Bruze, Magnus
• Is Part Of: Dermatitis. Volume 33:Issue 1(2022)
• Page Start: 31
• Page End: 35
• Publication Date: 2021-09-09
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000787
• Languages: English
• ISSNs: 1710-3568

Abstract

Abstract : Background: Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH. Objective: We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients. Methods: Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010–2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017. Results: A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of the 5448 adults (0.9%) and 10 of the 196 children (5.1%) were diagnosed with aluminum contact allergy. A significant difference was found between the aluminum allergy frequencies in children and adults patch tested with ACH in 2013–2017 ( P < 0.001). The difference between the frequencies of contact allergies for the 2 aluminum salts is not statistically significant. Conclusions: Patch testing with ACH and AL demonstrated similar contact allergy frequencies. To detect aluminum allergy, patch testing with ACH 10.0% pet is recommended. Aluminum chloride hexahydrate 10.0% pet should be considered for inclusion in baseline series for patch testing adults and children.