Two cytotoxic squalene-derived polyethers from the Japanese red alga Chondria armata. Issue 23 (2nd December 2021)

• Record Type: Journal Article
• Authors: Hamada, Toshiyuki; Kobayashi, Kazushi; Arima, Naomichi; Tani, Fumito; Vairappan, Charles Santhanaraju; Onitsuka, Satoaki; Okamura, Hiroaki
• Is Part Of: Natural product research. Volume 35:Issue 23(2021)
• Page Start: 5075
• Page End: 5080
• Publication Date: 2021-12-02
• Subjects: Chondria armata -- Rhodomelaceae -- red alga -- cytotoxicity -- triterpenoids -- adult T-cell leukemia -- S1T; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1777411
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The red alga Chondria armata is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga C. armata from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A (1 ) and B (2 ). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), 1 H-NMR, APT, 1 H– 1 H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC50 values are reported here. Graphical Abstract: